Preterm birth and licorice consumption during pregnancy. Lipids Health Dis 2011;10:29. Horm.Res 1999;52(5):253-255. Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: a randomized controlled study. The author has an hindex of 4, co-authored 18 publication(s) receiving 46 citation(s). Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. Asl, M. N. and Hosseinzadeh, H. Review of pharmacological effects of Glycyrrhiza sp. View abstract. Sakamoto S, Kudo H, Suzuki S, et al. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis -- double blind trial. J Tradit.Chin Med 2010;30(1):47-50. View abstract. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: Aspirin; Clopidogrel; Warfarin; St. John's wort. Licorice (Glycyrrhizae Radix) 15 g: NR: Zhao (2016) [36] . [Clinical study on effect of recombinant roasted licorice decoction combined with low-dose glucocorticoids in treating idiopathic thrombocytopenic purpura]. N Engl J Med. Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial. Part 182 -- Substances Generally Recognized As Safe. View abstract. Mohire, N. C. and Yadav, A. V. Chitosan-based polyherbal toothpaste: as novel oral hygiene product. Am J Chin Med 2003;31:445-53. . View abstract. View abstract. J Steroid Biochem Mol Biol 1994;49:81-5. Du, J. H. and Dong, B. D. [Comparative study on clinical efficacy of using methotrexate singly or combined with total glucosides of Paeony in treating rheumatoid arthritis]. Eur J Clin Pharmacol 2010;66(8):805-810. PC-SPES, a dietary supplement for the treatment of hormone-refractory prostate cancer. View abstract. 1991;78(1-2):1-6. Kent UM, Aviram M, Rosenblat M, Hollenberg PF. Peony-glycyrrhiza decoction for antipsychotic-related hyperprolactinemia in women with schizophrenia: a randomized controlled trial. Why Black Licorice Can Make Your Heart Skip - Cleveland Clinic About Dr.Cope. Botanical names: Paeonia lactiflora, Paeonia suffruticosa, Paeonia veitchii How It Works Peony contains a unique glycoside called paeoniflorin. J Telemed Telecare. Information from this source is evidence-based and objective, and without commercial influence. View abstract. View abstract. View abstract. J Hum Hypertens 2001;15:549-52. Glycyrrhizin-Induced Pseudohyperaldosteronism: A Case Report. Robles BJ, Sandoval AR, Dardon JD, Blas CA. Messier, C., Epifano, F., Genovese, S., and Grenier, D. Licorice and its potential beneficial effects in common oro-dental diseases. Severe hypokalaemia with paralysis induced by small doses of liquorice. Case 30-2020: A 54-Year-Old Man with Sudden Cardiac Arrest. Man dies after eating bags of black licorice every day Phytother Res 2008;22(6):709-724. Mu Y, Zhang J, Zhang S, et al. Journal of Clinical Therapeutics Medicine. Aging Clin Exp Res. Paeoniae Radix-containing herbal medicine for patients with restless legs syndrome: A systematic review and meta-analysis. Clinical and immunological consequences of total glucosides of paeony treatment in Sjgren's syndrome: A randomized controlled pilot trial. This can increase the effects and side effects of corticosteroids. Goto, F., Asama, Y., and Ogawa, K. Sho-saiko-to-ka-kikyo-sekko as an alternative treatment for chronic tonsillitis to avoid surgery. Jin, C. Y., Wang, D. L., and Fang, Z. D. [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood]. View abstract. Armanini D, De Palo CB, Mattarello MJ, et al. View abstract. Medicinal herbs: modulation of estrogen action. Yu C, Fan X, Li Z, Liu X, Wang G. Efficacy and safety of total glucosides of paeony combined with acitretin in the treatment of moderate-to-severe plaque psoriasis: a double-blind, randomised, placebo-controlled trial. View abstract. Peony might block chemicals that can cause pain and swelling . Chem Pharm Bull (Tokyo) 1994;42(5):1056-1062. G Ital Dermatol Venereol 2010;145(6):789-792. Steroids 2004;69(11-12):763-766. In an ovarietctomized model, oral administration of a combination of white peony and licorice increased DHEA and serum estrogen concentration. J Clin Ther Med 1999;15:499-523. View abstract. A., Lee, S. H., and Lee, S. M. Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. Hajiaghamohammadi, A. View abstract. Kinoshita, H., Okabayashi, M., Kaneko, M., Yasuda, M., Abe, K., Machida, A., Ohkubo, T., Kamata, T., and Yakushiji, F. Shakuyaku-kanzo-to induces pseudoaldosteronism characterized by hypokalemia, rhabdomyolysis, metabolic alkalosis with respiratory compensation, and increased urinary cortisol levels. Jia, Y. Bai, Y. S., Zhou, C. Y., and Wang, J. Q. Akamatsu, H., Komura, J., Asada, Y., and Niwa, Y. 2012;18(4):534-543. View abstract. J Pharmacol Exp Ther 2006;316:1369-77. Brasseur, A. and Ducobu, J. Nutr Res 2012;32(2):85-92. Abe Y, Ueda T, Kato T, Kohli Y. Let's take a look at the forms, uses, and side effects of . Arase, Y., Ikeda, K., Murashima, N., Chayama, K., Tsubota, A., Koida, I., Suzuki, Y., Saitoh, S., Kobayashi, M., and Kumada, H. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. 2007;30(7):1271-7. Ai, M., Yamaguchi, T., Odaka, T., Mitsuhashi, K., Shishido, T., Yan, J., Seza, A., and Saisho, H. Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy. Nuisanceless biological compound pesticide and preparation method Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. Peters, M. C., Tallman, J. Fugh-Berman, A. Herb-drug interactions. Migraine. Association of emblica, licorice and belides as an alternative to hydroquinone in the clinical treatment of melasma. . A dose of 800 milligrams (mg) or more of licorice root per day has been linked to low potassium levels. An Med Interna 1995;12(1):33-35. The benefits of licorice root can be enjoyed as a tea, supplement, tincture, or topical treatment, and even as candies. View abstract. View abstract. View abstract. View abstract. Eur J Drug Metab Pharmacokinet. Bannister, B., Ginsburg, R., and Shneerson, J. Cardiac arrest due to liquoriceinduced hypokalaemia. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. Researchers from the University of Minnesota studied 50 atopic dogs in a randomized, double-blind, placebo-controlled trial. J Hum Hypertens 1995;9:345-8. Loop diuretics can also decrease potassium levels. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. They also have a range of other intriguing activities. Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Zhou, Y., Huang, Z., and Huang, T. [Clinical study of shengxue mixture in treating aplastic anemia]. 2018;38(2):617-8. Phytother Res 2008;22(2):141-148. A man in Massachusetts died after eating too much black licorice, which contains a compound known to be toxic in large doses, according to a new report. Ruiz-Granados, E. S., Shouls, G., Sainsbury, C., and Antonios, T. A salty cause of severe hypertension. Peony might have some of the same effects as estrogen. Alt Med Rev 2001;6:495-9. Am J Chin Med 2005;33(5):747-758. View abstract. Imtiaz, K. E. Sweet root, bitter pill: liquorice-induced hyperaldosteronism. Paeoniflorin, a constituent of white peony root, has demonstrated inhibition of testosterone synthesis in vitro, without affecting estradiol synthesis.It reduces testosterone production by the ovaries but not the adrenal glands. Too much black licorice, the federal agency says, can lead to "abnormal heart rhythms, as well as high blood pressure, edema (swelling), lethargy, and congestive heart failure." . View abstract. Helpful. Electronic Code of Federal Regulations. J Intern Med 1999;245:307-10. View abstract. View abstract. Benefits of licorice root: Uses, side effects, and more Neurology 2010;75(21):1939-1941. . View abstract. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. Health Benefits and Side Effects of White Peony Root - Epainassist Reuter, J., Merfort, I., and Schempp, C. M. Botanicals in dermatology: an evidence-based review. Armanini D, Lewicka S, Pratesi C, et al. Aoki, F., Nakagawa, K., Kitano, M., Ikematsu, H., Nakamura, K., Yokota, S., Tominaga, Y., Arai, N., and Mae, T. Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans. Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A. As I've all but cut out alcohol, I've tended to drink this tea before going to bed and sometimes during the day. View abstract. Paeonia lactiflora (Chinese peony) and Paeonia brownii (California peony) relax smooth muscle tissue with a particular affinity for the female reproductive tract. View abstract. View abstract. Eur.Arch.Paediatr.Dent 2010;11(6):274-278. Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. J Clin Endocrinol Metab 2003;88:2384-92. Licorice or Mulethi, also known as "Sweetwood", is an effective and potent medicinal herb. Zhong Xi Yi Jie He Za Zhi 1986;6:714-6, 707. Gulf J Oncolog 2021;1(37):42-47. Evaluation of contextual and demographic factors on licorice effects on reducing hot flashes in postmenopause women. Neth J Med 2005;63:119-20. Phytotherapy Research 1997;11:207-210. van Gelderen, C. E., Bijlsma, J. We currently have no information for PEONY overview. PCOS; Fertility; 25 - 45; Menopause; 45 - 60; Pregnancy 2019;35:329-41. View abstract. A double-blind, randomized, placebo-controlled, multicenter trial. Intern Med 2007;46:575-8. Braz J Infect Dis 2016;20(6):534-8. View abstract. [Peony tincture in the complex treatment of allergic dermatoses]. [Treatment of chronic hepatitis B. Digestion 2004;69:45-52. is tatcha violet c brightening serum safe for pregnancy Wu G, Wu N, Li T, et al. Inhibition of 11 beta hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. Bian, X., Xu, Y., Zhu, L., Gao, P., Liu, X., Liu, S., Qian, M., Gai, M., Yang, J., and Wu, Y. View abstract. . Although some people believe that peony tea is the tea with the lowest caffeine levels, actually peony tea has a high caffeine level, as much as 5%. According to research, the combination of . [A plant extract and its modified preparation in functional dyspepsia. Taking licorice and loop diuretics together might make potassium levels drop too low. View abstract. View abstract. View abstract. It might also decrease the effects of birth control pills. Visavadiya, N. P. and Narasimhacharya, A. V. Hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra (Linn) in rats. Hasegawa, J., Suyama, Y., Kinugawa, T., Morisawa, T., and Kishimoto, Y. Echocardiographic findings of the heart resembling dilated cardiomyopathy during hypokalemic myopathy due to licorice-induced pseudoaldosteronism. Plant Description. View abstract. Practitioners still sometimes suggest whole licorice for cough . Sheehan MP, Atherton DJ. View abstract. J Dermatolog Treat 2003;14(3):153-157. View abstract. J Clin Psychopharmacol 1997;17(3):234-235. J Peripher.Nerv.Syst. 2013 Nov;18(6):593-6. Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996;30:171-7. View abstract. (Glycyrrhiza glabra), it performs better, especially for relaxing muscles, reducing painful menstruation, as well as lowering serum and free testosterone levels in women with PCOS. Hypertension and the cortisol-cortisone shuttle. Intern Med 2017;56(2):175-9. Attou R, Redant S, Honore PM, Preseau T, Hantson P, De Bels D. Liquorice intoxication can lead to cardiac arrest! Life Sci 9-27-2002;71(19):2267-2277. Ital J Neurol Sci 1983;4(4):493-497. View abstract. Cancer Res 2000;60:5704-9.. View abstract. This week, The New England Journal of Medicine reported that a man with a poor diet died of cardiac arrest after eating a bag-and-a-half of black licorice daily for weeks. NOW Supplements, Licorice Root (Glycyrrhiza glabra) 450 mg, Herbal Supplement, 100 Veg Capsules 208. Chinese herbal medicine for atopic eczema. ['Licorice hypertension' also caused by licorice tea]. Medicinal uses of licorice through the millennia: the good and plenty of it. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. View abstract. Am J Chin Med 1992;20(3-4):313-317. View abstract. Low potassium levels can increase the side effects of digoxin. It's not suggested to take St. John's wort if you take blood thinners. Clinical trial of deglydyrrhizinized liquorice in gastric ulcer. Thom E and Wollan T. A controlled clinical study of kanjang mixture in the treatment of uncomplicated upper respiratory tract infections. Gupta D, Agrawal S, Sharma JP. J Ethnopharmacol 2002;81:101-4.. View abstract. Paeoniflorin - an overview | ScienceDirect Topics Birth outcome in relation to licorice consumption during pregnancy. View abstract. Licorice : Benefits, Precautions and Dosage | 1mg Another type of licorice, called DGL or deglycyrrhizinated licorice, does not seem to have the same side effects and is sometimes used to treat peptic ulcers, canker sores, and reflux (GERD). 1994;14:207-9, 195. . Sigurjonsdottir, H. A., Manhem, K., Axelson, M., and Wallerstedt, S. Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. View abstract. View abstract. Peony - Kaiser Permanente View abstract. View abstract. Antimicrobial isoflavanoids and related substances from Glycyrrhiza glabra L. var. Acharya SK, Dasarathy S, Tandon A, et al. Licorice reduces body fat mass in obese men and women. 5-10-2004;208(1):89-94. Lee, I. T., Lee, W. J., Tsai, C. M., Su, I. J., Yen, H. T., and Sheu, W. H. Combined extractives of red yeast rice, bitter gourd, chlorella, soy protein, and licorice improve total cholesterol, low-density lipoprotein cholesterol, and triglyceride in subjects with metabolic syndrome. [Application of dannang recipe no. Licorice extract inhibits the production of tyrosinase, in turn inhibiting the production of dark spots. Brit Med J 1952;1:360-361. Hum.Exp Toxicol. Arch Pharm Res 2003;26(10):832-839. View abstract. Dong quai grows at high altitudes in the cold, damp, mountains of China, Korea, and Japan. Some research suggests that licorice extract may help kill bacteria in the mouth that cause tooth decay. Licorice seems to change hormone levels in the body. Br J Clin Pharmacol 2008;66:572-4. View abstract. View abstract. 1991;11(4):199-202, 195. Man SC, Li XB, Wang HH, et al. Overview. A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers or health and adiposity. Licorice Extract for Skin: The Complete Guide - Byrdie Zhong Xi Yi Jie He Za Zhi 1990;10:101-2, 70. . Yoshida S, Takayama Y. Licorice-induced hypokalemia as a treatable cause of dropped head syndrome. OTHER NAME(S): Bai Shao, Chi Shao, Chinese Peony, Common Peony, C. Peony (Paeonia lactiflora) is an herb. View abstract. Also for White Peony, the plant that is used in traditional . Ruetzler K, Fleck M, Nabecker S, Pinter K, Landskron G, Lassnigg A, You J, Sessler DI. Contact Dermatitis 2021;85(4):454-455. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori. 6. Brush, J., Mendenhall, E., Guggenheim, A., Chan, T., Connelly, E., Soumyanath, A., Buresh, R., Barrett, R., and Zwickey, H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. The effects of dietary licorice flavonoid oil supplementation on body balance control in healthy middle-aged and older Japanese women undergoing a physical exercise intervention: a randomized, double-blind, placebo-controlled trial. Phytother.Res. Effect of Shakuyaku-kanzo-to (Tsumura TJ-68) on muscle cramps accompanying cirrhosis in a placebo-controlled double-blind parallel study. View abstract. Dying for a cup of tea. View abstract. View abstract. and its bioactive compounds. Cochrane Database Syst Rev 2004;4:CD002291. Lower potassium levels can cause those abnormal heart arrhythmias. View abstract. 2013 Jun;19(4):227-8. J Nutr Sci Vitaminol. Xie HJ, Yasar U, Sandberg M, Rane A. Paeoniae Radix, a traditional Chinese medicine, and CYP2C9 activity. Mechanism of anti-inflammatory action of glycyrrhizin: effect on neutrophil functions including reactive oxygen species generation. Lee, C. H., Park, S. W., Kim, Y. S., Kang, S. S., Kim, J. Z. View abstract. American Herbal Products Association's Botanical Safety Handbook, Second Edition. [Paeonia Lactiflora injection in treating chronic cor pulmonale with pulmonary hypertension]. Kormann R, Languille E, Amiot HM, Hertig A. View abstract. Int Endod.J 2011;44(1):51-58. QJM 2011;104(12):1093-1095. Rikknen K, Seckl JR, Heinonen K, Pyhl R, Feldt K, Jones A, Pesonen AK, Phillips DI, Lahti J, Jrvenp AL, Eriksson JG, Matthews KA, Strandberg TE, Kajantie E. Maternal prenatal licorice consumption alters hypothalamic-pituitary-adrenocortical axis function in children. View abstract. B., and Zhang, Z. J. However, taking too much licorice root may cause side effects. Feng ZT, Xu J, He GC, Cai SJ, Li J, Mei ZG. View abstract. The invention belongs to the field of biopesticides, and mainly discloses a nuisanceless biological compound pesticide and a preparation method thereof. Motherwort, Peony, Dong Quai, Lady's Mantle, Licorice, and Rose, Fennel, Alfalfa. Proanthocyanidins, flavonoids, tannins, polysaccharides, and paeoniflorin are all considered to contribute to the medicinal activity of various forms of peony. Part 2: Effect of glycyrrhizic acid on the course of illness]. Complement Ther Clin Pract. View abstract. Isr J Dent Sci 1989;2(3):153-157. View abstract. Isaia, G. C., Pellissetto, C., Ravazzoli, M., and Tamone, C. Acute adrenal crisis and hypercalcemia in a patient assuming high liquorice doses. View abstract. An evaluation of the efficacy of licorice gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study. Purnak, T., Ozaslan, E., Beyazit, Y., and Haznedaroglu, I. C. Upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper. Cassano, N., Mantegazza, R., Battaglini, S., Apruzzi, D., Loconsole, F., and Vena, G. A. It contains kojic acid, witch hazel, and licorice extracts that reduce melanin production and exfoliate . Case Rep Emerg Med. Licorice Root: Benefits, Uses, Precautions, and Dosage - Healthline The effect of Glycyrrhiza glabra L. on primary dysmenorrhea compared with ibuprofen: A randomized, triple-blind controlled trial. October 15, 2021. Mol Nutr Food Res 2006;50(11):1080-1086. Holtmann G, Madisch A, Juergen H, et al. Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. Effects of Paeoniae Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin. The effect of dong quai on menopausal symptoms is unknown. Licorice might increase how quickly midazolam is broken down by the body. View abstract. 2013 Sep;117(3):614-21. Kang, J. H., Park, Y. H., Choi, S. W., Yang, E. K., and Lee, W. J. Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells. Phytother Res 1988;2(3):140-145. View abstract. View abstract. Pseudohyperaldosteronism, liquorice, and hypertension. Cumming, A. M., Boddy, K., Brown, J. J., Fraser, R., Lever, A. F., Padfield, P. L., and Robertson, J. I. Deng, Y. Y., Chen, Y. P., Wang, L., Hu, Z., Jin, Y., Shen, L., Zhu, R., and Zhong, Y. Hidden Risks of Black Licorice | Rutgers University Zhong Yao Cai 2000;23:557-60. . Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28(4):314-317. View abstract. Ann Clin Biochem 2007;44(Pt 4):397-399. Ito, M., Sato, A., Hirabayashi, K., Tanabe, F., Shigeta, S., Baba, M., De Clercq, E., Nakashima, H., and Yamamoto, N. Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV). Total glucosides of peony ameliorates Sjogren's syndrome by affecting Th1/Th2 cytokine balance. View abstract. Postgrad Med J 2003;79:115-6.. View abstract. View abstract. In 1977, researchers reported the case of a 58-year-old woman who was eating a whopping 1.8 kilograms (about 63.5 ounces) of black licorice per week and went into cardiac arrest. Peony and its major constituent, paeoniflorin, improve radial maze performance impaired by scopolamine in rats. Rare case of black licorice poisoning kills man in Massachusetts Nihon Jinzo Gakkai Shi 2010;52(1):80-85. Lee, C. K., Park, K. K., Lim, S. S., Park, J. H., and Chung, W. Y. J Altern Complement Med 2009;15(4):439-443. Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. Armanini, D., Nacamulli, D., Francini-Pesenti, F., Battagin, G., Ragazzi, E., and Fiore, C. Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application. Kamei T, Kumano H, Iwata K, et al. J Clin Psychopharmacol 2016;36(6):572-9. The dogs treated with the herbal mixture saw a 37.5 percent improvement . J Med Liban 2012;60(2):117-119. Side-effects of low-potassium levels can include lethargy and abnormal heart rhythms. View abstract. Licorice can decrease how quickly the body breaks down corticosteroids.